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Biomedical Photonics




Brief Bio

Yu-Hui Zhang received her BS degree from Department ofApplied Chemistry, the University of Science and Technology of China in 1997. She obtained her Ph.D in organic chemistry from the University of Hong Kong in 2004. She worked as a Post Doctoral Research Fellow in Department of Microbiology and Molecular Genetics, Harvard Medical School (Prof. Suzanne Walker, supervisor) from 2004-2006. She has joined Britton Chance Center for Biomedical Photonics in WNLO since Oct. 2006.

Research Areas

  1. Photoactivatable organic probes for live-cell super-resolution imaging

  2. Developing new methods for in vivo labeling of neurons

  3. Fluorescent probes for optical imaging of live cells and organisms


1. C. Gong, X. Li, L. Xu, Y.-H. Zhang*, Target delivery of a gene into the brain using the RVG29-oligoarginine peptide,Biomaterials 2012, 33, 3456-3463.

2. Y. Ma, C. Gong, Y. Ma, F. Fan, M. Luo, F. Yang, Y.-H. Zhang*, Direct cytosolic delivery of cargoes in vivo by a chimera consisting of D- and L-arginine residues, J Control. Release 2012, 162, 286-294.

3. F. Fan, S. Nie, D. Yang, M. Luo, H. Shi, Y.-H. Zhang*, Labeling lysosomes and tracking lysosome-dependent apoptosis with a cell-permeable activity-based probe, Bioconjugate Chem. 2012, 23, 1309-1317.

4. Y. Ma, D. Yang, Y. Ma, Y.-H. Zhang*, Novel cell-penetrating peptides based on alpha-aminoxy acids, ChemBioChem2012, 13, 73-79.

5. F. Fan, S. Nie, E. B. Dammer, D. M. Duong, D. Pan, L. Ping, L. Zhai, J. Wu, X. Hong, L. Qin, P. Xu*, Y.-H. Zhang*, Protein profiling of active cysteine cathepsins in living cells using an activity-based probe containing a cell-penetrating peptide, J Proteome Res. 2012, 11, 5763−5772.

6. Y.-H. Zhang, K.Song, N.-Y.Zhu, D.Yang*, The effect of backbone stereochemistry on the folding of acyclic beta2,3 -aminoxy peptides, Chem. Eur. J. 2010, 16, 577-587.

7. D. Yang*, X.-W. Chang, D.-W. Zhang, Z.-F. Jiang, K.-S. Song, Y.-H. Zhang, N.-Y. Zhu, L.-H. Weng, M.-Q. Chen, Chiral alpha-aminoxy acid/achiral cyclopropane alpha-aminoxy acid unit as a building block for constructing the alpha N-O helix, J Org. Chem. 2010, 75, 4796-4805.

8. S. Brown, Y.-H. Zhang, S. Walker*, A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the tntracellular steps, Chem&Biol 2008, 15, 12-21.

9. Y.-H. Zhang, C. Ginsberg, Y. Yuan, S. Walker*, Acceptor substrate selectivity and kinetic mechanism of bacillus subtilis TagA in vitro, Biochemistry 2006, 45, 10895-10904.

10. C. Ginsberg, Y.-H. Zhang, Y. Yuan, S. Walker*, In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis using synthetic substrate analogs, ACS Chem. Biol. 2006, 1, 25-28.

11. D. Yang*, Y.-H. Zhang, B. Li, D.-W. Zhang, J. C.-Y. Chan, N.-Y. Zhu, S.-W. Luo, Y.-D. Wu, Effect of side chains on turns and helices in peptides of beta3-aminoxy acids, J Am. Chem. Soc. 2004, 126, 6956-6966.

12. D. Yang*, Y.-H. Zhang, B. Li, D.-W. Zhang, The synthesis of chiral beta3-aminoxy peptides, J Org. Chem. 2004, 69, 7577-7581.

13. D. Yang*, Y.-H. Zhang, N.-Y. Zhu, β2,2-aminoxy acids: a new building block for turns and helices, J Am. Chem. Soc.2002, 124, 9966-9967.

14. D. Yang*, J. Qu, W. Li, Y.-H. Zhang, Y. Ren, D.-P. Wang, Y.-D. Wu, Cyclic hexapeptide of D,L-alpha-aminoxy acids as a selective receptor for chloride ion, J Am. Chem. Soc. 2002, 124, 12410-12411.


  • The National High-Tech Research and Development Program of China (863 Program: 2008AA02Z107)

  • The National Natural Science Foundation of China (Grant No. 30800183)

  • The National Natural Science Foundation of China (Grant No. 31270906)

  • The Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (Yu-Hui Zhang)

  • The Key Scientific Research Foundation of Huazhong University of Science and Technology (Grant No. 2006Z016B)

Awards and Honors

Professional Activities

Research & Faculty